When you run OpenEmu, all of the systems you see in the list are supported “out of the box.” It’s a mouse-driven UI designed to focus on your ROM collection, organized by system. OpenEmu’s strength is its MacOS-native interface.
Thanks to OpenEmu ( covered here previously), emulation of about 30 consoles “just works.” We also now have RetroArch, a competing multi-system emulator that works on far more than just MacOS.
You no longer have to “get your hands dirty” to emulate a ton of game consoles on MacOS. Clearly I have not been updating this blog, but one of the reasons for that is that emulation has become much more user-friendly in the past few years.